nicotine pancreatic
Question: Benefiting nicotine pancreatitis or pancreatic carcinoma?
response from Dr. Andrea Riphaus, PD Dr. Till Wehrmann, Medical Clinic I, Klinikum Hannover-Siloam: Besides the already known factors such as advanced age, sex, religion, and alcohol abuse could in the past Years, cigarette smoking as a risk factor for the development or aggravation of pancreatic diseases are identified. Thus, for in smokers demonstrate a 2.5 times increased risk for the occurrence of pancreatic cancer, especially women here seem endangered.
had in a case-control study of 754 subjects compared to 70% of smokers at increased risk for pancreatic cancer with non-smokers. The study could also be shown that after termination of nicotine decreased the incidence of pancreatic cancer. Another case-control study from Japan shows that nicotine is associated often than chance with chronic pancreatitis, regardless of Alcohol consumption. The current data can therefore be concluded that nicotine is an independent, relevant risk factor for chronic pancreatitis. The latter in turn increased in several studies, the risk for the development of pancreatic cancer - and up to 16 times. So far not fully understood, pathogenic mechanisms which are responsible for it. Because nicotine acts in its original composition is not a carcinogen per se. Presumably, however, it is biotransformed to its ingestion and is then able to modify proteins and DNA (Kokarzinogen). In a rat model of nicotine
accumulated to a greater extent in the pancreas and in other regions of the gastrointestinal tract, and the present in tobacco smoke Nitrosoderviate on animals have shown a carcinogenic potential of the pancreas. In mice, nicotine caused similar morphological changes such as caerulein: it formed an interstitial edema, cytoplasmic vacuolization, pyknotic nuclei and a Karyorrhexis. Such changes are also found in chronic pancreatitis. This suggests that nicotine by oxidative stress altered the acinar cells and thus trigger pancreatitis and can entertain. In conclusion, the available information, an association between smoking and chronic pancreatitis and pancreatic cancer, without the mechanisms responsible for this, so far in the Details are clarified.
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